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Overview
Penicillin G Benzathine is a long-acting antibiotic salt produced via the reaction of benzylpenicillin with benzathine. Its molecular formula is C34H48N6O10S2 and CAS number is 1405-47-0.
Application
- Rheumatic Fever Prophylaxis: Monthly intramuscular injections for preventing recurrence in patients with history of rheumatic heart disease.
- Syphilis Treatment: Primary therapy for early syphilis and latent syphilis due to sustained serum concentrations.
- Streptococcal Infections: Management of group A streptococcal pharyngitis and tonsillitis.
Precautions
Strictly contraindicated for intravenous or intra-arterial administration due to risk of fatal embolization. Store below 25°C in dry conditions away from light. Monitor for hypersensitivity reactions prior to use.