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Overview
Perindopril tert-butylamine is the active pharmaceutical ingredient (API) salt form of a widely used angiotensin-converting enzyme (ACE) inhibitor. Synthesized via coupling perindopril with tert-butylamine, this compound features the molecular formula C21H34N2O5 and CAS number 97460-79-8. It serves as a critical intermediate for oral antihypertensive formulations.
Application
- Manufacturing of tablets for hypertension management.
- Production of combination therapies for heart failure.
- Pharmaceutical research on renin-angiotensin system modulation.
Precautions
Strictly contraindicated in patients with history of angioedema or bilateral renal artery stenosis. Store in cool, dry conditions below 25°C to maintain chemical stability and prevent hydrolysis.