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Overview
Ponatinib Hydrochloride is a potent, oral tyrosine kinase inhibitor designed for oncology. Its synthesis involves advanced organic coupling and salt formation processes. The compound features the molecular formula C25H21ClN4O·HCl with CAS No. 984467-03-8.
Application
- Oncology Manufacturing: API production for treating chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).
- Research & Development: Used in clinical trials to evaluate efficacy against T315I mutations.
- Contract Manufacturing: Sourced by pharmaceutical firms for bulk drug substance formulation.
Precautions
Strictly contraindicated in patients with severe arterial occlusive events. Requires storage under controlled temperature (2-8°C) in moisture-proof containers. Handling mandates PPE due to potential cytotoxicity and vascular risks.