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Home Products Antiparasitic
Praziquantel
Praziquantel

Praziquantel

Category:
Antiparasitic
CAS NO:
55268-74-1
Standard:
USP,In-house Standards,
Price Range:
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Main Sales Markets:
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Basic Info

CAS Number
55268-74-1
Pharmacopoeia
USP,In-house Standards
Grade
Pharmaceutical grade、 veterinary grade
Is Manufacturer
YES
Samples Provided
YES

Product Description

[name] Praziquantel
【 CAS NO.】 55268-74-1
【 characteristics 】 this product is white or white crystalline powder; Bitter taste. Easily dissolved in chloroform, dissolve in ethanol, insoluble in water or ethyl ether.   
[pharmacological action] (1) the insect body muscle tetanic contraction and a spastic paralysis is generated. Schistosomiasis is only 20 seconds after exposure to low concentration praziquantel insect body tension is increased, the concentrations of more than 1 mg/L, insect body emitting a strong contracture. Insect body muscle contraction with praziquantel increased insect cell membrane permeability, make the loss of calcium ion in cells.
(2) the worm cortex damage and participate in host immune function: praziquantel is rapid and significant for worm cortex damage, cause syncytial in vitro skin swelling, cavitation, form the bulla, highlight the body surface and eventually skin erosion dyke break, secretion body almost all disappear, dissolve ring of muscle and longitudinal muscle was successively. Visible in the host, 15 minutes after taking the drug in vitro skin vacuoles degeneration. Cortical destruction, the impact of insect body absorption and excretion function, more important is its surface antigen exposure, which are vulnerable to the host immune attack, a large number of acidophilic granulocyte attached and invade in skin lesions, prompting insect body death. In addition, praziquantel can also cause secondary changes, make the insect body table membrane depolarization, cortex significantly lower activity of alkaline phosphatase, cause glucose uptake inhibition, endogenous sex glycogen depletion. Praziquantel can also inhibit insect body nucleic acid and protein synthesis.
Praziquantel for limited 】 【 worm has obvious inhibitory effect of glucose metabolism, affect insect body of glucose is taken; Promote glycogen decomposition in the body, make glycogen significantly reduced or disappeared. Praziquantel for broad-spectrum parasite drug resistance of schistosoma japonicum, schistosoma mf and schistosoma Egypt testosterone trematode, lung trematode, fasciolopsis buski, tapeworm and cysticercosis were effective. Praziquantel is the ideal new broad-spectrum resistance to tapeworm and drug resistance to schistosomiasis, widely used in the world at present. Praziquantel for schistosomiasis, tapeworm and cysticercosis, wha testosterone trematode, lung trematode, fasciolopsis buski were effective.
【 usage and dosage 】 oral: a quantity, each 1 kg weight, cattle, sheep, pigs, 10 ~ 35 mg; Dogs, cats, 2.5 ~ 5 mg.
【 notes 】 (1) in the treatment of parasitic in the organization of parasites such as worms, lung trematode, cysticercosis, etc., was killed because of the insect body after release a large amount of antigen, can cause fever, acidophilic granulocyte increased, skin rash, accidentally can cause anaphylactic shock, must pay attention to watch. When in cysticercosis repel with tapeworm, need to should be hidden except brain cysticercosis, so as to avoid accidents.
(2) the large dose of subcutaneous injection, can appear sometimes local stimulus response. Dogs, cats, the whole body reaction (born at a rate of 10%) for pain, vomiting, diarrhea, salivate, the phenomenon such as weakness, lethargy, but more than ability.
(3) used for fish inappropriate medication before gastric disorder 1, megalobrama amblycephala should be careful.