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Overview
Progesterone is a naturally occurring steroid hormone essential for the regulation of the menstrual cycle and pregnancy. It is primarily synthesized via semi-synthesis from diosgenin derived from wild yams or through microbial fermentation.
- Molecular Formula: C21H30O2
- CAS Number: 57-83-0
Application
- Hormone Replacement Therapy (HRT): Used to treat menopausal symptoms and prevent endometrial hyperplasia in postmenopausal women.
- Fertility Treatments: Critical component in assisted reproductive technologies (ART) to support embryo implantation and maintain early pregnancy.
- Gynecological Disorders: Management of abnormal uterine bleeding and premenstrual dysphoric disorder (PMDD).
Precautions
- Contraindicated in patients with active thromboembolic disorders, severe liver impairment, or undiagnosed vaginal bleeding.
- Requires storage in cool, dry conditions below 25°C away from direct light to ensure chemical stability.
- Prolonged use without medical supervision may increase risks of cardiovascular events.