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Overview
(R)-(-)-1-[(S)-2-(DICYCLOHEXYLPHOSPHINO)FERROCENYL]ETHYLDI-T-BUTYLPHOSPHINE, known as Josiphos, is a chiral diphosphine ligand used in asymmetric catalysis. Its molecular formula is C40H58P2Fe and CAS number is 126975-23-9.
Application
- Pharmaceutical Synthesis: Enantioselective hydrogenation of functionalized olefins to produce chiral intermediates for drug manufacturing.
- Agricultural Chemicals: Asymmetric synthesis of active ingredients for herbicides and pesticides requiring high optical purity.
- Fine Chemicals: Production of optically pure alcohols and amines via rhodium or ruthenium-catalyzed reactions.
Precautions
- Store under inert atmosphere (nitrogen/argon) at low temperatures to prevent oxidation and degradation.
- Handle in a fume hood using appropriate PPE; avoid contact with skin and eyes due to potential irritancy.
- Not intended for direct clinical use; strictly for industrial chemical processing applications only.