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Overview
Rabeprazole is a proton pump inhibitor synthesized via heterocyclic chemistry. It suppresses gastric acid secretion by irreversibly blocking the H+/K+-ATPase enzyme system. The molecular formula is C17H19N3O3S2, and its CAS registry number is 117976-90-4.
Application
- Gastroenterology: Treatment of gastroesophageal reflux disease (GERD) and erosive esophagitis.
- Ulcer Management: Healing of duodenal and gastric ulcers, including those associated with NSAID use.
- H. pylori Eradication: Component of combination therapies for Helicobacter pylori infection.
Precautions
Contraindicated in patients with hypersensitivity to substituted benzimidazoles. Long-term use may require monitoring for magnesium deficiency and bone fractures. Store in a dry place below 25°C, protected from light and moisture to maintain stability.