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Overview
Regorafenib Monohydrate is a multi-kinase inhibitor synthesized via crystallization. Its molecular formula is C20H14ClF3N6O and CAS No. is 871033-59-3.
Application
- Oncology: Treatment of metastatic colorectal cancer, gastrointestinal stromal tumors, and hepatocellular carcinoma.
- Research: In vitro studies on angiogenesis inhibition and tumor cell proliferation.
Precautions
Contraindicated in severe hepatic impairment. Requires storage below 25°C in dry conditions. Strict PPE is mandatory during handling due to cytotoxicity.