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Overview
Rimegepant is a potent, orally active small-molecule CGRP receptor antagonist developed for the treatment of migraine. Its core synthesis involves complex heterocyclic coupling to achieve high selectivity. The chemical formula is C24H26N8O5S with CAS No. 1977370-77-6.
Application
- Neurology: Acute abortive therapy for migraine attacks with or without aura.
- Preventive Care: Monthly dosing regimen for episodic migraine prophylaxis.
Precautions
Contraindicated in patients with severe hepatic impairment. Avoid co-administration with strong CYP3A4 inhibitors. Store under controlled room temperature away from moisture and light to maintain stability.