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Overview
Roflumilast is a potent, selective phosphodiesterase-4 (PDE4) inhibitor used primarily in respiratory medicine. Synthesized via specialized organic chemistry routes involving pyridine derivatives, its chemical structure is defined by the molecular formula C17H18N2O4S and CAS number 162197-09-7.
Application
- Pharmaceutical Manufacturing: Active pharmaceutical ingredient (API) for treating severe COPD associated with chronic bronchitis.
- Research & Development: Tool compound for investigating inflammatory pathways and pulmonary diseases.
- Contract Manufacturing: Bulk supply for generic drug formulation and tablet production.
Precautions
Strictly contraindicated in patients with moderate to severe hepatic impairment. Requires storage in a cool, dry environment below 25°C away from direct sunlight. Handling mandates appropriate PPE due to potential irritant properties.