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Overview
Sacubitril Valsartan Sodium (LCZ696) is a fixed-dose combination of a neprilysin inhibitor and an angiotensin II receptor blocker. Molecular Formula: C41H48N5NaO9. CAS No.: 1027240-25-4. Core synthesis involves coupling sacubitril acid with valsartan sodium salt under controlled conditions.
Application
- Cardiovascular Therapeutics: First-line treatment for chronic heart failure to reduce hospitalization and mortality risks.
- Pharmaceutical Manufacturing: Active Pharmaceutical Ingredient (API) used in tablet formulations for global distribution.
- Clinical Research: Standard comparator in trials evaluating novel antihypertensive mechanisms.
Precautions
Contraindicated in patients with history of angioedema or severe renal impairment. Store API in airtight containers at 2°C–8°C away from direct sunlight. Strict adherence to GMP protocols required during handling to ensure purity and safety.