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Overview
Sarecycline is a narrow-spectrum, second-generation tetracycline antibiotic primarily used in dermatology. Its core synthesis involves the selective halogenation of oxytetracycline derivatives. The chemical formula is C22H20N2O8 with CAS number 17944-56-4.
Application
- Dermatology: Treatment of moderate-to-severe acne vulgaris via topical or oral administration.
- Ophthalmology: Management of bacterial conjunctivitis due to its favorable ocular penetration.
- Infectious Diseases: Alternative therapy for specific respiratory infections where broader agents are contraindicated.
Precautions
Contraindicated in children under eight years and pregnant women due to teeth discoloration risks. Store below 25°C in dry conditions away from light. Patients must avoid concurrent use with calcium-rich foods or antacids to prevent reduced absorption.