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Overview
SELUMETINIB BASE is a potent, selective inhibitor of MEK1 and MEK2 enzymes. The core synthesis involves advanced organic coupling reactions to achieve high purity. Its molecular formula is C20H17F3N4O with CAS No. 953638-18-5.
Application
- Oncology Research: Development of targeted therapies for RAS/MAPK pathway-driven tumors.
- Pharmaceutical Manufacturing: API production for metastatic colorectal cancer and thyroid cancer treatments.
- Quality Control: Reference standard usage in analytical method validation for drug substances.
Precautions
Strictly for research use only; not approved for direct human administration without formulation. Store under inert atmosphere at -20°C. Handle with appropriate PPE due to potential mutagenicity.