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*The following content is generated by AI and is for reference only.
Overview
Sitagliptin is a potent, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor used primarily in diabetes management. Synthesized via advanced chiral catalysis, its molecular formula is C16H15F6N5O with CAS No. 486460-32-8.
Application
- Pharmaceutical Manufacturing: Active pharmaceutical ingredient (API) for type 2 diabetes drugs.
- Formulation Industry: Key component in combination therapies with metformin or pioglitazone.
- R&D Sector: Reference standard for bioequivalence studies and stability testing.
Precautions
Strictly contraindicated in patients with severe renal impairment or history of pancreatitis. Store API in sealed containers at 2-8°C to maintain chemical stability and prevent hydrolysis.