Category:
Chiral Intermediates
CAS NO:
767340-03-4
Standard:
In-house Standards,
sitagliptin intermediate-5
CAS#:767340-03-4
purity:more than 98%
package: aluminum foil bag,bucket
Sitagliptin intermediate-5, chemically identified as (R)-2-amino-4-(4-fluorophenyl)butanamide, is a critical chiral building block for synthesizing the DPP-4 inhibitor sitagliptin. The core process involves asymmetric hydrogenation or enzymatic resolution of 4-(4-fluorophenyl)-2-butenamide. Its molecular formula is C10H11FN2O and CAS number is 1396728-36-7.
Store in a cool, dry place under inert atmosphere to prevent hydrolysis. Personnel must wear PPE including respirators and chemical-resistant gloves due to potential irritancy. Not for direct human consumption; strictly regulated as an industrial intermediate.