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Overview
Sivelestat Sodium is a selective neutrophil elastase inhibitor used in acute respiratory distress syndrome. Synthesized via chiral resolution, its molecular formula is C14H20N4O5S and CAS number is 168728-94-9.
Application
- Treatment of ARDS associated with systemic inflammatory response syndrome.
- Mitigation of organ damage during cardiopulmonary bypass surgery.
- Adjunct therapy for severe pancreatitis to reduce neutrophil infiltration.
Precautions
Contraindicated in patients with known hypersensitivity. Store at controlled room temperature (20°C–25°C) in dry conditions. Monitor renal function closely during infusion due to excretion via kidneys.