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Overview
Sonidegib (LDE225) is a potent, oral small-molecule inhibitor of the Hedgehog signaling pathway. Its molecular formula is C28H30F4N6O3 with CAS number 971374-98-4. The compound is synthesized via multi-step organic chemistry to target Smoothened.
Application
- Oncology: Treatment of locally advanced or metastatic basal cell carcinoma.
- R&D: Research tool for studying Hedgehog pathway dysregulation in tumors.
Precautions
Strictly contraindicated in pregnancy due to teratogenicity. Requires controlled storage at 20°C–25°C in moisture-proof containers. Handling demands PPE to prevent dermal absorption and inhalation risks.