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Overview
Tacrolimus monohydrate is a potent macrolide immunosuppressant produced via microbial fermentation of Streptomyces tsukubaensis. Its chemical structure corresponds to the formula C44H75NO12 with CAS 104987-11-3.
Application
- Transplantation Medicine: Prophylaxis of organ rejection in renal, hepatic, and cardiac allografts.
- Dermatology: Topical treatment for moderate-to-severe atopic dermatitis.
- Autoimmune Disorders: Management of refractory conditions unresponsive to conventional therapies.
Precautions
Strictly contraindicated in patients with hypersensitivity to tacrolimus or macrolides. Requires rigorous temperature control (2°C–8°C) and protection from light to maintain stability. Clinical use demands therapeutic drug monitoring due to a narrow therapeutic index.