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Overview
Tandutinib is a potent, oral small-molecule tyrosine kinase inhibitor (TKI) specifically targeting the c-Kit and PDGFR pathways. The chemical formula is C20H19ClN4O with CAS number 857626-39-6. It is synthesized via multi-step organic coupling to ensure high purity for pharmaceutical development.
Application
- Oncology Research: Investigational agent for GIST and mastocytosis trials.
- Drug Discovery: Standard compound for screening c-Kit mutations.
- Biochemical Assays: Used in vitro to study receptor phosphorylation inhibition.
Precautions
Strictly for research use only; not approved for clinical therapy. Store at -20°C under inert atmosphere. Handle with PPE due to potential cytotoxicity and sensitization risks.