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Overview
Tegafur (TS-1) is a fluoropyrimidine prodrug synthesized via chemical modification of uracil. It serves as an oral precursor to 5-fluorouracil, primarily used in oncology formulations like TS-1. Its molecular formula is C8H7FN2O2 with CAS number 50-96-6.
Application
- Oncology Therapy: First-line treatment for gastric and colorectal cancers.
- Combination Regimens: Co-administered with cisplatin or leucovorin to enhance efficacy.
- Chemical Intermediate: Used in pharmaceutical synthesis for antineoplastic drug development.
Precautions
Strictly contraindicated in patients with severe bone marrow suppression. Requires storage below 25°C in dry conditions. Handling mandates PPE due to potential carcinogenicity and teratogenic effects during manufacturing.