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Overview
Tenofovir Alafenamide (TAF) is a prodrug of tenofovir designed for enhanced cellular delivery. It features optimized pharmacokinetics with lower systemic exposure compared to TDF. Molecular formula: C19H28N5O7P; CAS No.: 1409960-06-8.
Application
- Antiviral Therapy: Treatment of chronic HIV-1 infection and HBV in adults.
- Pharmaceutical Formulation: Key API in fixed-dose combination tablets and capsules.
- Research: Used in clinical trials for novel nucleotide analog regimens.
Precautions
Contraindicated in severe renal impairment without dose adjustment. Store below 25°C in moisture-proof containers. Handle with standard PPE to avoid inhalation or skin contact during manufacturing.