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Overview
Tenofovir Alafenamide Fumarate is a prodrug of tenofovir designed for enhanced cellular uptake. Its molecular formula is C20H31N6O7P·C4H4O4 with CAS No. 1450389-79-1. The core synthesis involves selective phosphorylation and esterification.
Application
- HIV Treatment: Component in fixed-dose combinations for antiretroviral therapy.
- Hepatitis B: First-line agent for chronic HBV infection management.
- Pharmaceutical Manufacturing: API supply for generic tablet production.
Precautions
Strictly contraindicated for patients with severe renal impairment without dosage adjustment. Store in sealed containers below 25°C to prevent hydrolysis. Handle with PPE to avoid skin contact during manufacturing.