Category:
Prophylactic Biological Products
CAS NO:
1392275-56-7
Standard:
In-house Standards,
Tenofovir alafenamide hemifumarate
N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester, (2E)-2-butenedioate (2:1)
CAS:1392275-56-7
Tenofovir alafenamide hemifumarate is a prodrug of tenofovir, optimized for oral bioavailability and reduced systemic exposure. Synthesized via esterification and salt formation, its molecular formula is C14H20N5O8P·C4H4O4 (CAS 1350736-32-9).
Contraindicated in patients with severe renal impairment without dose adjustment. Requires storage below 25°C in moisture-controlled environments to maintain stability. Monitor bone mineral density during long-term therapy.