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Overview
This compound is a critical pharmaceutical intermediate for the synthesis of venetoclax, a BCL-2 inhibitor. It features a pyrrolopyridine scaffold coupled with a bromobenzoate moiety. Molecular Formula: C17H16BrN3O4; CAS No.: 1597283-50-1. The core process involves nucleophilic substitution and esterification under strict anhydrous conditions.
Application
- Pharmaceutical manufacturing: Key building block for oncology API production.
- Medicinal chemistry: Used in lead optimization for hematological malignancies.
- Contract research: Supplier for custom synthesis of targeted therapies.
Precautions
Requires storage in sealed containers at 2-8°C away from moisture. Handle with PPE to avoid skin contact; inhalation may cause respiratory irritation. Regulatory compliance is mandatory for clinical trial supply chains.