Category:
Other Specialized Reagents
CAS NO:
58479-61-1
Standard:
USP,BP,EP,In-house Standards,
Tert-butyl dimethyl chlorosilane (TBDMSCl) is a widely used silylating reagent for protecting hydroxyl groups in organic synthesis. The core process involves nucleophilic substitution where the chloride acts as a leaving group. Its molecular formula is C6H15ClSi and CAS number is 18162-48-6.
This compound is moisture-sensitive and corrosive; it releases HCl upon contact with water. Strict storage in sealed containers under inert atmosphere is mandatory. Personal protective equipment including goggles and gloves must be worn during handling to prevent severe skin and eye irritation.