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Overview
Tetramethylurea (TMU) is a polar aprotic solvent and chemical intermediate. Produced via phosgenation of dimethylamine, its molecular formula is C5H12N2O with CAS No. 68-12-2.
Application
- Pharmaceuticals: Used as a reaction medium for peptide synthesis and drug crystallization.
- Polymer Chemistry: Serves as a solvent for cellulose derivatives and polyimides.
- Organic Synthesis: Functions as a non-nucleophilic base in various coupling reactions.
Precautions
Store in a cool, dry place away from oxidizers. Avoid skin contact due to potential irritation; use appropriate PPE including gloves and eye protection during handling.