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Overview
Tocilizumab is a humanized monoclonal antibody targeting the interleukin-6 receptor. Manufactured via recombinant DNA technology, its molecular formula is C7412H11506N1980O2312S46 (CAS: 536127-34-1).
Application
- Rheumatology: Treatment of moderate-to-severe rheumatoid arthritis.
- Oncology: Management of cytokine release syndrome in CAR-T therapy.
- Immunology: Therapy for systemic juvenile idiopathic arthritis.
Precautions
Contraindicated in active severe infections; requires monitoring of liver enzymes and lipid levels. Store vials at 2°C to 8°C protected from light; do not freeze or shake.