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Overview
Tofacitinib Citrate is the citrate salt of a Janus kinase (JAK) inhibitor, synthesized via condensation of tofacitinib free base with citric acid. Molecular Formula: C20H28N6O7; CAS No.: 1259073-47-8.
Application
- Rheumatology: Treatment of moderate-to-severe rheumatoid arthritis.
- Dermatology: Management of active psoriatic arthritis and alopecia areata.
- Gastroenterology: Induction and maintenance of remission in ulcerative colitis.
Precautions
Contraindicated in patients with severe hepatic impairment or active serious infections. Store below 25°C in dry, light-resistant conditions to maintain stability and potency.