Category:
Other Antibiotics
CAS NO:
/
Standard:
In-house Standards,
Topotecan is a semi-synthetic camptothecin analog antineoplastic agent. It functions as a potent topoisomerase I inhibitor, disrupting DNA replication via the formation of stable enzyme-DNA cleavable complexes. The chemical formula is C20H26N2O7, with CAS number 123948-87-8.
Strictly controlled as a cytotoxic substance requiring PPE during handling. Storage must be maintained at 2-8°C in light-resistant containers to prevent degradation. Contraindicated in patients with severe neutropenia or hypersensitivity to camptothecins.