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Overview
Topotecan hydrochloride is a semi-synthetic camptothecin derivative used as an antineoplastic agent. Manufactured via chemical synthesis, its molecular formula is C23H29ClN2O8 and CAS number is 123948-87-8.
Application
- Oncology: Treatment of small cell lung cancer and ovarian cancer.
- Pharmaceutical Manufacturing: Active Pharmaceutical Ingredient (API) for intravenous formulations.
- Clinical Research: Investigational use in combination chemotherapy regimens.
Precautions
Strictly contraindicated during pregnancy due to embryotoxicity. Requires storage in cool, dry conditions away from light. Personnel must utilize appropriate PPE to prevent dermal exposure.