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Overview
Tozasertib (VX-978) is a potent, oral Aurora kinase inhibitor developed for oncology. Its core synthesis involves complex heterocyclic coupling to target the ATP-binding site of Aurora A and B kinases. Molecular formula: C26H24F3N5O3; CAS No.: 1380596-74-8.
Application
- Clinical Research: Investigated in Phase II trials for solid tumors including pancreatic cancer and lymphoma.
- Pharmaceutical Manufacturing: Sourced as active pharmaceutical ingredient (API) for targeted therapy formulations.
- Biochemical Assays: Used in vitro to study cell cycle regulation and mitotic spindle assembly mechanisms.
Precautions
Strictly store under inert atmosphere at -20°C to prevent hydrolysis. Handle with appropriate PPE due to potential cytotoxicity; avoid inhalation or skin contact during industrial processing.