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*The following content is generated by AI and is for reference only.
Overview
Trabectedin is a marine-derived antineoplastic agent isolated from the tunicate Ecteinascidia turbinata. It functions as a DNA minor groove binder interfering with transcription-coupled nucleotide excision repair. Molecular Formula: C45H67N5O10S; CAS No.: 182918-93-0.
Application
- Oncology Manufacturing: Production of injectable formulations for advanced soft tissue sarcomas and ovarian cancer.
- Contract Development: API synthesis services for global pharmaceutical contract manufacturing organizations (CMOs).
- R&D Supply: Provision of high-purity reference standards for clinical trial investigational new drug applications.
Precautions
Strictly indicated for second-line therapy in specific malignancies after prior chemotherapy failure. Requires specialized handling due to cytotoxicity; store at controlled room temperature away from light. Avoid direct contact during compounding to prevent occupational exposure risks.