Category:
Prophylactic Biological Products
CAS NO:
77-86-1
Standard:
In-house Standards,
Tromethamine, also known as THAM, is a non-buffering organic amine used primarily as a pH regulator in pharmaceutical formulations. Synthesized via the reaction of tris(hydroxymethyl)aminomethane with ammonia, its molecular formula is C4H11NO3 (CAS No. 77-86-1).
Strictly contraindicated in patients with severe respiratory depression or hypercapnia due to potential CO2 retention. Requires storage in tightly sealed containers at controlled temperatures below 25°C to prevent degradation.