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Overview
Upadacitinib is a potent, selective JAK1 inhibitor developed for autoimmune disorders. Its core synthesis involves advanced organic coupling and chiral resolution techniques. Molecular formula: C24H29N7O2; CAS No.: 2068580-44-4.
Application
- Rheumatoid arthritis management in patients with inadequate response to methotrexate.
- Treatment of moderate-to-severe atopic dermatitis.
- Therapeutic intervention for active psoriatic arthritis.
- Management of ankylosing spondylitis cases.
Precautions
Contraindicated in severe hepatic impairment or active serious infections. Storage requires controlled room temperature (20-25°C) in dry, light-resistant containers to maintain chemical stability during logistics and handling.