Category:
Active Pharmaceutical Ingredients
CAS NO:
644981-35-1
Standard:
In-house Standards,
Val-Cit-PAB-MMAE is a cleavable linker-drug payload used in Antibody-Drug Conjugates (ADCs). Its valine-citrulline dipeptide sequence ensures enzymatic release by cathepsin B. The molecule features a PAB spacer and monomethyl auristatin E cytotoxic agent. Molecular formula: C45H72N8O10; CAS No.: 269731-52-8.
Store at -20°C under inert atmosphere. Handle with PPE due to potent cytotoxicity; avoid inhalation or skin contact. Clinical use requires strict regulatory compliance and specialized waste disposal protocols.