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Overview
Valaciclovir HCl is the L-valyl ester prodrug of acyclovir, designed for enhanced oral bioavailability. Synthesized via enzymatic or chemical esterification, its molecular formula is C13H20N6O4·HCl (CAS No. 124832-23-5).
Application
- Viral Infection Therapy: Treatment of herpes zoster and genital herpes.
- Immunocompromised Patients: Suppression of recurrent outbreaks in HIV/AIDS populations.
- Prophylaxis: Prevention of cytomegalovirus (CMV) infection in transplant recipients.
Precautions
Dose adjustment required for renal impairment. Store below 25°C in dry conditions to prevent hydrolysis. Monitor for neurological side effects in elderly patients.