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Overview
Valdecoxib is a potent, selective COX-2 inhibitor used in pharmaceutical synthesis. Its core process involves chiral resolution and sulfonamide coupling. The molecular formula is C17H18N2O4S with CAS No. 169590-11-8.
Application
- Rheumatology: Management of osteoarthritis pain.
- Orthopedics: Treatment of acute pain following surgery.
- Gynecology: Alleviation of primary dysmenorrhea symptoms.
Precautions
Strictly contraindicated for patients with sulfa allergies or history of coronary bypass surgery. Store under inert atmosphere at 2-8°C to maintain stability and prevent hydrolysis.