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Overview
VESATOLIMOD (GS-9620) is a potent, selective oral agonist of the TLR7 receptor. Its chemical formula is C18H25N7O2 with CAS No. 1469224-36-3. The core process involves synthesizing a pyrimidine-based nucleoside analog designed to mimic viral RNA structures.
Application
- Viral Hepatitis: Investigated for chronic HBV and HCV treatment via immune activation.
- Oncology: Studied as an adjuvant in cancer immunotherapy to enhance T-cell responses.
- Immunology: Utilized in research for modulating innate immune pathways.
Precautions
Development halted due to insufficient efficacy in late-stage trials. Handle under controlled conditions; store at -20°C in sealed containers to maintain stability against hydrolysis.