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Overview
Vinflunine is a semi-synthetic microtubule inhibitor derived from vinblastine, utilized primarily in oncology. It features a unique difluorovinyl moiety enhancing stability and potency. Molecular Formula: C45H52F2N4O9; CAS No.: 167805-21-6.
Application
- Chemotherapy for metastatic urothelial carcinoma post-platinum failure.
- Treatment of advanced non-small cell lung cancer (NSCLC) in specific regimens.
- Research into novel taxane-vinca hybrid antineoplastic agents.
Precautions
Contraindicated in severe hepatic impairment or neutropenia. Strict PPE required during handling to prevent dermal absorption. Store under controlled conditions at -20°C to maintain chemical integrity.