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Overview
Wang Resin is a polystyrene-based solid support functionalized with a 4-hydroxymethylphenoxy group, serving as the cornerstone for Fmoc and Boc solid-phase peptide synthesis. The core structure features a benzyl alcohol linker attached to chloromethylated polystyrene beads.
Application
- Peptide Synthesis: Standard substrate for automated synthesizers in pharmaceutical R&D.
- Library Construction: Essential for generating combinatorial chemical libraries in drug discovery.
- Fragment Coupling: Used for attaching specific moieties during complex molecule assembly.
Precautions
Store under inert atmosphere at room temperature to prevent premature hydrolysis. Handle with nitrile gloves in fume hoods due to potential cytotoxicity of residual solvents. Avoid strong oxidizing agents during cleavage processes.