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Overview
Z-Valine NCA (N-Carboxyanhydride) is a cyclic activated amino acid derivative used primarily for the synthesis of polypeptides via ring-opening polymerization. The core process involves reacting Z-valine with phosgene or triphosgene under anhydrous conditions. Molecular Formula: C14H16N2O5; CAS No.: 59738-05-3.
Application
- Peptide Synthesis: Serving as a monomer for automated solid-phase peptide synthesis to create specific sequences.
- Drug Delivery: Fabricating biodegradable polymeric carriers for targeted drug release systems.
- Biomaterials: Engineering scaffolds for tissue engineering and regenerative medicine applications.
Precautions
Strictly store in a dry, inert atmosphere below -20°C to prevent hydrolysis. Handle with appropriate PPE due to potential respiratory irritancy. Not approved for direct clinical use without further formulation and regulatory clearance.