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Overview
Ziconotide Acetate is a synthetic calcium channel blocker derived from cone snail venom, utilized for severe chronic pain management. Produced via recombinant DNA technology and subsequent acetylation, its molecular formula is C128H195N41O36S with CAS No. 170865-35-9.
Application
- Intrathecal Analgesia: Treatment of severe chronic pain in patients refractory to other therapies.
- Pain Management Centers: Adjunct therapy for cancer-related or neuropathic pain unresponsive to opioids.
- Clinical Research: Investigational use in non-opioid analgesic protocols.
Precautions
- Administration: Strictly intrathecal only; fatal if administered intravenously.
- Storage: Maintain at controlled room temperature (20°C–25°C) protected from light.
- Monitoring: Requires close psychiatric and neurological observation due to CNS side effects.