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*The following content is generated by AI and is for reference only.
Overview
Zofenoprilat is the active carboxylate metabolite of zofenopril, a thiol-containing angiotensin-converting enzyme (ACE) inhibitor. Synthesized via enzymatic hydrolysis or chemical de-esterification, its molecular formula is C18H24N2O5S with CAS number 97330-62-2.
Application
- Hypertension Management: Used in pharmaceutical formulations for lowering blood pressure.
- Heart Failure Therapy: Adjunct treatment to reduce cardiac workload and improve survival rates.
- Post-Myocardial Infarction: Utilized to prevent ventricular remodeling after acute heart attacks.
Precautions
Contraindicated in patients with history of angioedema or bilateral renal artery stenosis. Requires strict storage under controlled temperature and humidity to maintain stability against oxidation. Handling requires PPE to avoid inhalation of dust particles.