(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R,3R)-2,3-dihydroxybutanedioate is an important intermediate for Ticagrelor.
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R,3R)-2,3-dihydroxybutanedioate is a chiral salt intermediate primarily synthesized via asymmetric hydrogenation or resolution of racemic cyclopropylamines. This pharmaceutical building block features the molecular formula C11H12F2N2O6. While specific CAS numbers vary by supplier for the salt form, it serves as a critical precursor in modern medicinal chemistry.
Store under inert atmosphere at 2-8°C to prevent hydrolysis. Handle with appropriate PPE due to potential sensitization risks. Ensure strict compliance with GMP standards during clinical drug manufacturing processes.