Category:
Active Pharmaceutical Ingredients
CAS NO:
1
Standard:
USP;BP,
Acalabrutinib, Afatinib, Axitinib, and Cabozantinib S-Malate are high-purity kinase inhibitors used in oncology. Acalabrutinib (CAS 1205678-29-2) targets BTK; Afatinib (CAS 459890-48-1) inhibits EGFR/HER2; Axitinib (CAS 950247-67-9) blocks VEGFR; Cabozantinib S-Malate (CAS 1232405-77-6) targets MET/VEGFR. Core synthesis involves advanced organic coupling and salt formation.
Strictly store below -20°C in dry, inert atmospheres. Handle with PPE to prevent dermal absorption. Clinical use requires monitoring for hypertension and bleeding risks under professional supervision.