A member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis.
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Overview
Apremilast is a selective phosphodiesterase-4 (PDE4) inhibitor used in dermatology. Molecular Formula: C21H26N4O5. CAS Number: 901372-86-3.
Application
- Treatment of moderate-to-severe plaque psoriasis.
- Management of active psoriatic arthritis.
- Oral therapy for patients with limited efficacy from biologics.
Precautions
Monitor for gastrointestinal adverse events and weight loss. Store below 30°C in dry conditions. Contraindicated in severe hepatic impairment.