Enteric capsule is the kind of capsule that cannot dissolve in the gastric juice but can disintegrate in the succus entericus and release active constituents as its shell is added some specific medicinal high molecular materials or processes particularly; The reason why enteric capsules are made is that some drugs is not harmful for intestines but have very strong irritation to stomach.
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Overview
An Enteric Capsule is a specialized dosage form designed to resist gastric acid and release active pharmaceutical ingredients in the intestine. Core manufacturing involves coating capsules with pH-sensitive polymers like Hypromellose Phthalate. Key parameters include molecular formula C20H30O11 (for HPMC-AP) and CAS 9004-65-7.
Application
- Gastrointestinal Therapeutics: Protects acid-labile drugs like proton pump inhibitors.
- Pain Management: Delivers NSAIDs directly to the small intestine to minimize gastric irritation.
- Enzyme Replacement: Ensures pancreatic enzymes survive stomach acidity for effective digestion.
Precautions
Store in a cool, dry place below 25°C to prevent premature coating degradation. Do not crush or chew capsules as this compromises the enteric barrier. Ensure strict adherence to patient-specific acid secretion profiles during clinical prescribing.