Filgotinib (maleate) is a selective and orally active JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM and 116 nM for JAK1, JAK2, JAK3 and TYK2, respectively. Filgotinib (maleate) can be used for rheumatoid arthritis (RA) and Crohn's disease research
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Overview
Filgotinib maleate is a selective JAK1 inhibitor used in pharmaceutical synthesis. Its molecular formula is C24H29FN6O4 with CAS No. 1588974-75-5.
Application
- Rheumatology: Treatment of rheumatoid arthritis.
- Oncology: Investigational use for inflammatory malignancies.
- Biochemical Research: Target validation for JAK-STAT pathway studies.
Precautions
Store below 25°C in a dry, dark environment. Strictly monitor hepatotoxicity risks and avoid use during pregnancy due to teratogenic potential.