Lapatinib (GW572016) is a potent EGFR and ErbB2 inhibitor with IC50s of 10.2 and 9.8 nM, respectively.
*The following content is generated by AI and is for reference only.
Overview
Lapatinib (GW572016) is a small-molecule tyrosine kinase inhibitor targeting HER2 and EGFR. Molecular Formula: C29H24ClFN4O3; CAS No.: 231277-92-2. Synthesis involves multi-step organic coupling with high-purity chromatography.
Application
- Oncology: Treatment of HER2-positive breast cancer in combination with capecitabine.
- Pharmaceutical R&D: Used as a reference standard for kinase assay development.
- Chemical Manufacturing: Serves as an intermediate API for formulation studies.
Precautions
Strictly store at -20°C in inert atmosphere. Avoid direct contact due to potential hepatotoxicity and skin irritation. Clinical use requires monitoring of cardiac function and liver enzymes.