Mesna (2-mercaptoethane sulfonate sodium) is a thiol-containing compound used primarily as an uroprotective agent. It prevents hemorrhagic cystitis induced by oxazaphosphorine alkylating agents like cyclophosphamide and ifosfamide through rapid neutralization of toxic acrolein metabolites. The core process involves intravenous or oral administration to bind reactive intermediates in the urinary tract. Chemical Formula: C2H5NaO3S2, CAS No.: 1098-71-1.
Strictly contraindicated for patients with known hypersensitivity to mesna or sulfur compounds. Requires careful monitoring of renal function in patients with pre-existing kidney impairment. Store in tightly sealed containers at controlled room temperature (15-25°C) away from light to prevent oxidation and maintain chemical stability.